diff --git a/CHANGELOG.md b/CHANGELOG.md
index d183c45d..8aca8f15 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -23,6 +23,7 @@ and this project adheres to
 
 ### Added
 
+- Support upstreams for subdomains of a domain only ([#4503]).
 - Support for Discovery of Designated Resolvers (DDR) according to the [RFC
   draft][ddr-draft-06] ([#4463]).
 - The ability to control each source of runtime clients separately via
@@ -150,6 +151,7 @@ In this release, the schema version has changed from 12 to 14.
 [#4273]: https://github.com/AdguardTeam/AdGuardHome/issues/4273
 [#4276]: https://github.com/AdguardTeam/AdGuardHome/issues/4276
 [#4499]: https://github.com/AdguardTeam/AdGuardHome/issues/4499
+[#4503]: https://github.com/AdguardTeam/AdGuardHome/issues/4503
 [#4533]: https://github.com/AdguardTeam/AdGuardHome/issues/4533
 [#4542]: https://github.com/AdguardTeam/AdGuardHome/issues/4542
 
diff --git a/go.mod b/go.mod
index 8da34653..4d9d2191 100644
--- a/go.mod
+++ b/go.mod
@@ -3,7 +3,7 @@ module github.com/AdguardTeam/AdGuardHome
 go 1.17
 
 require (
-	github.com/AdguardTeam/dnsproxy v0.42.2
+	github.com/AdguardTeam/dnsproxy v0.42.4
 	github.com/AdguardTeam/golibs v0.10.8
 	github.com/AdguardTeam/urlfilter v0.16.0
 	github.com/NYTimes/gziphandler v1.1.1
diff --git a/go.sum b/go.sum
index 807a6849..73accb25 100644
--- a/go.sum
+++ b/go.sum
@@ -7,8 +7,8 @@ dmitri.shuralyov.com/html/belt v0.0.0-20180602232347-f7d459c86be0/go.mod h1:JLBr
 dmitri.shuralyov.com/service/change v0.0.0-20181023043359-a85b471d5412/go.mod h1:a1inKt/atXimZ4Mv927x+r7UpyzRUf4emIoiiSC2TN4=
 dmitri.shuralyov.com/state v0.0.0-20180228185332-28bcc343414c/go.mod h1:0PRwlb0D6DFvNNtx+9ybjezNCa8XF0xaYcETyp6rHWU=
 git.apache.org/thrift.git v0.0.0-20180902110319-2566ecd5d999/go.mod h1:fPE2ZNJGynbRyZ4dJvy6G277gSllfV2HJqblrnkyeyg=
-github.com/AdguardTeam/dnsproxy v0.42.2 h1:aBhbuvqg/rZN8Rab5ILSfPFJDkiTviWXXcceJgajnNs=
-github.com/AdguardTeam/dnsproxy v0.42.2/go.mod h1:thHuk3599mgmucsv5J9HR9lBVQHnf4YleE08EbxNrN0=
+github.com/AdguardTeam/dnsproxy v0.42.4 h1:Rf45a3H6U/8XqWMYAMEsC1g/dVudyfgx4WY8N2syJMw=
+github.com/AdguardTeam/dnsproxy v0.42.4/go.mod h1:thHuk3599mgmucsv5J9HR9lBVQHnf4YleE08EbxNrN0=
 github.com/AdguardTeam/golibs v0.4.0/go.mod h1:skKsDKIBB7kkFflLJBpfGX+G8QFTx0WKUzB6TIgtUj4=
 github.com/AdguardTeam/golibs v0.4.2/go.mod h1:skKsDKIBB7kkFflLJBpfGX+G8QFTx0WKUzB6TIgtUj4=
 github.com/AdguardTeam/golibs v0.10.4/go.mod h1:rSfQRGHIdgfxriDDNgNJ7HmE5zRoURq8R+VdR81Zuzw=
diff --git a/internal/dnsforward/http.go b/internal/dnsforward/http.go
index 2b7cfd13..50ab9643 100644
--- a/internal/dnsforward/http.go
+++ b/internal/dnsforward/http.go
@@ -510,6 +510,7 @@ func separateUpstream(upstreamStr string) (upstream string, isDomainSpec bool, e
 			continue
 		}
 
+		host = strings.TrimPrefix(host, "*.")
 		err = netutil.ValidateDomainName(host)
 		if err != nil {
 			return "", true, fmt.Errorf("domain at index %d: %w", i, err)